Sodium Hydroxide → HCID 44456288, compound

HRID 494573Notes

Reaction equation

HRID 494573 reaction equation
[CH:1]1([CH2:7][C:8]2([CH3:37])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([OH:18])=[C:10]([C:19]3[NH:24][C:23]4[CH:25]=[CH:26][C:27]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:28][C:22]=4[S:21](=[O:35])(=[O:34])[N:20]=3)[C:9]2=[O:36])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+:39]>O>[CH:1]1([CH2:7][C:8]2([CH3:37])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([O-:18])=[C:10]([C:19]3[NH:24][C:23]4[CH:25]=[CH:26][C:27]([NH:29][S:30]([CH3:33])(=[O:32])=[O:31])=[CH:28][C:22]=4[S:21](=[O:34])(=[O:35])[N:20]=3)[C:9]2=[O:36])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[Na+:39]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 136152975HCID 136152975, compound

Product 1

HCID 44456288HCID 44456288, compoundYield 60.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
25 °C

Procedure

A suspension of the product of Example 41I (0.968 g) in water (5 mL) and treated with 0.997N sodium hydroxide solution (1.78 mL, 1.77 mmol) and stirred at 25° C. for 1 hour. The solution was lyophilized to give the title compound (0.602 g, 60%). 1H NMR (300 MHz, DMSO-d6): δ ppm 0.75 (m, 6H) 1.10 (m, 1H) 1.38 (m, 7H) 1.75 (m, 1H) 2.22 (m, 1H) 2.95 (m, 3H) 7.31 (m, 3H) 7.45 (m, 3H) 8.05 (m, 1H) 9.87 (m, 1H) 15.55 (m, 1H). MS (ESI−) m/z 542 (M−H)−.

Sources & evidence

ORD record
ord-44c6289d02854a0caa86d029e6d2972f
Source dataset
uspto-grants-2009_05
Patent number
US07538105B2

Reaction notes

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