HRID494618
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
A mixture of Example 103A (10.0 mg, 0.016 mmol) and 0.998 M sodium hydroxide (0.016 mL, 0.016 mmol) in water (1 mL) was stirred at rt for 16 h. The reaction mixture was concentrated in vacuo to give the title compound (10.0 mg, quant. yield). 1H NMR (300 MHz, DMSO-d6) δ 0.40 (m, 1H) 0.65 (d, J=6.62 Hz, 3H) 0.67 (m, 3H) 0.76 (m, 1H) 1.27 (m, 1H) 1.34 (s, 3H) 1.69 (m, 1H) 2.11 (m, 1H) 7.26 (m, 4H) 7.43 (m, 2H) 7.64 (m, 2H) 7.75 (dd, J=8.46, 1.84 Hz, 1H) 8.03 (m, 4H) 8.38 (s, 1H) 10.54 (s, 1H) 15.37 (s, 1H). MS (ESI+) m/z 630.0 (M+H−Na)+, 647.1.0 (M−Na+NH4)+.
WORKUP
后处理
- concentrationThe reaction mixture was concentrated in vacuo