Sodium Hydroxide → Sodium (4r)-4-methyl-4-(3-methylbutyl)-2-{7-[(2-naphthylsulfonyl)amino]-1,1-dioxido-4h-1,2,4-benzothiadiazin-3-yl}-3-oxo-3,4-dihydronaphthalen-1-olate

Participants

Reaction Steps

A mixture of Example 103A (10.0 mg, 0.016 mmol) and 0.998 M sodium hydroxide (0.016 mL, 0.016 mmol) in water (1 mL) was stirred at rt for 16 h. The reaction mixture was concentrated in vacuo to give the title compound (10.0 mg, quant. yield). 1H NMR (300 MHz, DMSO-d6) δ 0.40 (m, 1H) 0.65 (d, J=6.62 Hz, 3H) 0.67 (m, 3H) 0.76 (m, 1H) 1.27 (m, 1H) 1.34 (s, 3H) 1.69 (m, 1H) 2.11 (m, 1H) 7.26 (m, 4H) 7.43 (m, 2H) 7.64 (m, 2H) 7.75 (dd, J=8.46, 1.84 Hz, 1H) 8.03 (m, 4H) 8.38 (s, 1H) 10.54 (s, 1H) 15.37 (s, 1H). MS (ESI+) m/z 630.0 (M+H−Na)+, 647.1.0 (M−Na+NH4)+.

Provenance & Evidence