反应详情

温度

60 °C

To a solution of Example 181C (42 mg, 0.16 mmol) in methanol (1 mL) was added a solution of 1 N NaOH (0.5 mL, 0.5 mmol). The reaction solution was stirred at 60° C. for 96 h. The solution was cooled to room temperature, acidified with 0.1 N HCl, and extracted with ethyl acetate (3× 1 mL). The combined organic extracts were dried (Na2SO4) and concentrated in vacuo. Column chromatography on silica (20%-40% ethyl acetate/hexane) afforded product as an off-white solid (24 mg, 60%).

1. temperatureThe solution was cooled to room temperature
2. extractionextracted with ethyl acetate (3× 1 mL)
3. dry with materialThe combined organic extracts were dried (Na2SO4)
4. concentrationconcentrated in vacuo