Piperidine → 4-(4-{2-[2-(1-Piperidinyl)ethyl]-1-benzofuran-5-yl}benzoyl)morpholine

HRID 494781Notes

Reaction equation

HRID 494781 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[O:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1)(=O)=O.[NH:31]1[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1>>[N:31]1([CH2:6][CH2:7][C:8]2[O:9][C:10]3[CH:16]=[CH:15][C:14]([C:17]4[CH:18]=[CH:19][C:20]([C:23]([N:25]5[CH2:30][CH2:29][O:28][CH2:27][CH2:26]5)=[O:24])=[CH:21][CH:22]=4)=[CH:13][C:11]=3[CH:12]=2)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 222745312-{5-[4-(4-Morpholinylcarbonyl)phenyl]-1-benzofuran-2-yl}ethyl methanesulfonate

Product 1

HCID 103198694-(4-{2-[2-(1-Piperidinyl)ethyl]-1-benzofuran-5-yl}benzoyl)morpholine

Procedure

The product from Example 23D and piperidine were processed as described in Example 1D to provide the titled compound. 1H NMR (300 MHz, CD3OD) δ 7.82 (m, 1H), 7.73 (d, J=8.1, 2H), 7.54 (m, 2H), 7.51 (d, J=8.1 Hz, 2H), 6.77 (s, 1H), 3.32-3.8 (m, 14H), 3.07 (m, 2H), 1.5-2.1 (m, 6H); MS (DCI) m/z 419 (M+H)+;

Sources & evidence

ORD record
ord-6e54ba583c0c4604b23d60f184e08ef3
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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