2-Methylpiperidine → 4-(4-{2-[2-(2-Methyl-1-piperidinyl)ethyl]-1-benzofuran-5-yl}benzoyl)morpholine

HRID 494783Notes

Reaction equation

HRID 494783 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]([N:25]4[CH2:30][CH2:29][O:28][CH2:27][CH2:26]4)=[O:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1)(=O)=O.[CH3:31][CH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][NH:33]1>>[CH3:31][CH:32]1[CH2:37][CH2:36][CH2:35][CH2:34][N:33]1[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[CH:19][C:20]([C:23]([N:25]4[CH2:26][CH2:27][O:28][CH2:29][CH2:30]4)=[O:24])=[CH:21][CH:22]=3)=[CH:13][C:11]=2[CH:12]=1

Participants

3

Reactant 2

HCID 79742-MethylpiperidineHCID 222745312-{5-[4-(4-Morpholinylcarbonyl)phenyl]-1-benzofuran-2-yl}ethyl methanesulfonate

Product 1

HCID 117435504-(4-{2-[2-(2-Methyl-1-piperidinyl)ethyl]-1-benzofuran-5-yl}benzoyl)morpholine

Procedure

The product from Example 23D and 2-methyl-piperidine were processed as described in Example 1D to provide the titled compound. 1H NMR (300 MHz, CD3OD) δ 7.82 (m, 1H), 7.74 (d, J=8.1, 2H), 7.56 (m, 2H), 7.52 (d, J=8.1 Hz, 2H), 6.80 (s, 1H), 3.4-3.78 (m, 15H), 1.6-2.1 (m, 6H), 1.46 (d, J=6.3 Hz, 3H); MS (DCI) m/z 433 (M+H)+;

Sources & evidence

ORD record
ord-891b225fb56e4a4d930c8ce174477910
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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