2-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl Methanesulfonate → 4-(2-{2-[(2S)-2-methylpyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile

HRID 494890Notes

Reaction equation

HRID 494890 reaction equation
Br.[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][NH:4]1.CS(O[CH2:13][CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)=[CH:20][C:18]=2[CH:19]=1)(=O)=O>>[CH3:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:13][CH2:14][C:15]1[O:16][C:17]2[CH:23]=[CH:22][C:21]([C:24]3[CH:29]=[CH:28][C:27]([C:30]#[N:31])=[CH:26][CH:25]=3)=[CH:20][C:18]=2[CH:19]=1

Participants

3

Reactant 2

HCID 113936782-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl MethanesulfonateHCID 20779371(S)-2-methylpyrrolidine hydrobromide

Product 1

HCID 112559884-(2-{2-[(2S)-2-methylpyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile

Procedure

(2S)-2-Methylpyrrolidine hydrobromide and the product from Example 1C can be processed as described in Example 1D to provide the title compound.

Sources & evidence

ORD record
ord-dd485778fd2548bbbbec8eb6807602e6
Source dataset
uspto-grants-2009_05
Patent number
US07538138B2

Reaction notes

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