HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Hydroxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one → 1-{1-[2-(6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Hydroxy-2-methyl-3,4-dihydroisoquinolin-1(2H)-one | HCID 10583440 | — |
| Reactant | 1-{1-[2-(6-Methoxy-1-methyl-2-oxo-1,4-dihydro-2H-benz[d](1,3]oxazin-7-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide | HCID 57682771 | — |
| Reactant | 1-{1-[2-(7-Methoxy-3,3-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-1H-indole-6-carboxamide | HCID 57682789 | — |
| Reactant | 7-Allyl-6-methoxy-1,4-dihydrobenz[d][1,3]oxazin-2-one | HCID 57682804 | — |
| Product | 1-{1-[2-(6-methoxy-2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide | HCID 57682923 | — |
Reaction Steps
The subject compound was synthesized from 6-hydroxy-2-methyl-3,4-dihydro-2H-isoquinolin-1-one (CAS#: 308110-07-8) according to the methods described in Example 22, (1), (2) and (3), and Example 23, (5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07538123B2 |
| Source dataset | uspto-grants-2009_05 |
| ORD ID | ord-5e81da7b9daf493aa78098a88cfbf53a |
| Source note | uspto-grants-2009_05 |