反应详情

259 mg of 1-(1-(2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl)piperidin-4-yl)-N-methyl-1H-indole-6-carboxamide was dissolved in 5 ml of methanol. Thereafter, 60 mg of sodium borohydride was added to the reaction solution while cooling on ice. The obtained mixture was then stirred at room temperature overnight. Thereafter, a saturated sodium bicarbonate aqueous solution was added to the reaction solution, followed by extraction with methylene chloride. The extract was dried over magnesium sulfate and then concentrated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate) and then purified by silica gel column chromatography (ethyl acetate-methanol), so as to obtain 216 mg of the subject compound.

1. temperaturewhile cooling on ice
2. extractionfollowed by extraction with methylene chloride
3. dry with materialThe extract was dried over magnesium sulfate
4. concentrationconcentrated under a reduced pressure
5. customThe residue was purified by NH silica gel column chromatography (ethyl acetate)
6. custompurified by silica gel column chromatography (ethyl acetate-methanol)