反应详情

温度

70 °C

100 mg of 7-(2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)ethyl)-6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline was dissolved in 6 ml of 2 N hydrochloric acid-tetrahydrofuran (1:1). The reaction solution was stirred at 70° C. for 7 hours. The reaction solution was cooled to a room temperature. Thereafter, a saturated sodium bicarbonate aqueous solution was added to the reaction solution, followed by extraction with methylene chloride. The extract was dried over magnesium sulfate and then concentrated under a reduced pressure, so as to obtain 87 mg of 1-(2-(6-methoxy-1-methyl-1,2,3,4-tetrahydroquinolin-7-yl)ethyl)piperidin-4-one. This compound was used in the following reaction without further purification.

1. temperatureThe reaction solution was cooled to a room temperature
2. extractionfollowed by extraction with methylene chloride
3. dry with materialThe extract was dried over magnesium sulfate
4. concentrationconcentrated under a reduced pressure