tert-Butyl methyl ether → 1-(1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide maleate

Participants

Reaction Steps

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (105 mg) was dissolved in tetrahydrofuran (10 ml). Thereafter, a tetrahydrofuran solution (10 ml) containing maleic acid (25 mg) was added to the reaction solution at room temperature. Thereafter, t-butyl methyl ether was added thereto at room temperature, and the obtained mixture was then concentrated under a reduced pressure. Diethyl ether was added to the residue for solidification. This suspension was stirred for 10 minutes while cooling on ice, and a solid was then collected by filtration. The solid was washed with diethyl ether, so as to obtain the subject compound (117 mg).

Provenance & Evidence