反应详情

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (105 mg) was dissolved in tetrahydrofuran (10 ml). Thereafter, a tetrahydrofuran solution (10 ml) containing maleic acid (25 mg) was added to the reaction solution at room temperature. Thereafter, t-butyl methyl ether was added thereto at room temperature, and the obtained mixture was then concentrated under a reduced pressure. Diethyl ether was added to the residue for solidification. This suspension was stirred for 10 minutes while cooling on ice, and a solid was then collected by filtration. The solid was washed with diethyl ether, so as to obtain the subject compound (117 mg).

1. additionwas added to the reaction solution at room temperature
2. concentrationat room temperature, and the obtained mixture was then concentrated under a reduced pressure
3. additionDiethyl ether was added to the residue for solidification
4. temperaturewhile cooling on ice
5. filtrationa solid was then collected by filtration
6. washThe solid was washed with diethyl ether