反应详情

1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (1.00 g) and fumaric acid (0.249 g) were dissolved in a mixed solvent consisting of acetone (5 ml) and water (15 ml) at 60° C. Thereafter, the reaction solution was left at room temperature for 1 hour. The deposited solid was collected by filtration. The collected crystal was washed with a mixed solvent consisting of acetone (2.5 ml) and water (7.5 ml), so as to obtain the subject compound (1.09 g).

1. filtrationThe deposited solid was collected by filtration
2. washThe collected crystal was washed with a mixed solvent