Acetone → DN9H25S82Z

Participants

Reaction Steps

1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (1.00 g) and fumaric acid (0.249 g) were dissolved in a mixed solvent consisting of acetone (5 ml) and water (15 ml) at 60° C. Thereafter, the reaction solution was left at room temperature for 1 hour. The deposited solid was collected by filtration. The collected crystal was washed with a mixed solvent consisting of acetone (2.5 ml) and water (7.5 ml), so as to obtain the subject compound (1.09 g).

Provenance & Evidence