反应详情

4-Iodophenylacetic acid (3 g), ethanol (20 mL) and conc. H2SO4 (5 mL) were refluxed overnight. Ca. 15 mL ethanol was then evaporated, the residue was extracted with dichloromethane (3×100 mL), the combined organic extracts were washed with sat. aq. NaHCO3, dried over Na2SO4 and evaporated in vacuo to afford 2.97 g (90%) of 121JP58 as a yellow oil.

1. custom15 mL ethanol was then evaporated
2. extractionthe residue was extracted with dichloromethane (3×100 mL)
3. washthe combined organic extracts were washed with sat. aq. NaHCO3
4. dry with materialdried over Na2SO4
5. customevaporated in vacuo