Anisole → HCID 60139039, compound

Temperature

45 °C

To the mixture of N-(trifluoroacetyl)-D-alanine (10.00 g; 0.054 mol) and pyridine (100 μl) in CH2Cl2 (100 ml), thionyl chloride (4.1 ml; 0.057 mol) is added dropwise at room temperature and then stirred for 7 hours at 45° C. Anisole (7.0 ml; 0.065 mol) is added and the solution is cooled on an ice-bath. AlCl3 (7.92 g; 0.059 mol) is added in portions and stirred at room temperature for 36 hours. The reaction is terminated with the addition of cold 1M HCl (150 ml) and ice (100 ml). The organic phase is washed with 1M HCl (2×100 ml), water (2×100 ml), saturated NaHCO3 solution (2×100 ml), dried over anhydrous sodium sulphate and concentrated. Heptane (35 ml) is added to the residue while stirring. The formed para-product is filtered off and washed with heptane (2×25 ml). White needle-like crystals are obtained: 4.80 g (32,3% yield); >99% e.e.; [α]57923−40.4; [α]54623−47.0 (c 1.0; MeOH), ortho-product assay 1-2%, melting point 110-114° C., 1H-NMR (CDCl3): 1.52 (d, 3H, CH3; J=7.2 Hz); 3.91 (s, 3H, MeO); 5.47 (m, 1H, CH); 7.00 (m, 2H, H-2.6); 7.64 (broad s, 1H, NHCOCF3); 7.97 (m, 2H, H-3.5).

1. additionis added dropwise at room temperature
2. temperaturethe solution is cooled on an ice-bath
3. stirringstirred at room temperature for 36 hours
4. customThe reaction is terminated with the addition of cold 1M HCl (150 ml) and ice (100 ml)
5. washThe organic phase is washed with 1M HCl (2×100 ml), water (2×100 ml), saturated NaHCO3 solution (2×100 ml)
6. dry with materialdried over anhydrous sodium sulphate
7. concentrationconcentrated
8. additionHeptane (35 ml) is added to the residue
9. stirringwhile stirring
10. filtrationThe formed para-product is filtered off
11. washwashed with heptane (2×25 ml)
12. customWhite needle-like crystals are obtained

ORD record

ord-590b8e04fb5a40d194657450ecd874ae

Source dataset

uspto-grants-2009_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07538246B2