Pyridine → HCID 66593465, compound

HRID 495158Notes

Reaction equation

HRID 495158 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]1[C:10](=[O:15])[CH2:11][CH2:12][C:13]=1[CH3:14].N1C=CC=CC=1.[C:22]1([CH3:34])[CH:27]=[C:26]([CH3:28])[CH:25]=[C:24]([CH3:29])[C:23]=1[S:30](Cl)(=[O:32])=[O:31]>>[C:22]1([CH3:34])[CH:27]=[C:26]([CH3:28])[CH:25]=[C:24]([CH3:29])[C:23]=1[S:30]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]1[C:10](=[O:15])[CH2:11][CH2:12][C:13]=1[CH3:14])(=[O:31])=[O:32]

Participants

4

Reactant 3

HCID 1049PyridineHCID 130462-Mesitylenesulfonyl chlorideHCID 66593777HCID 66593777, compound

Product 1

HCID 66593465HCID 66593465, compound

Procedure

0.700 g (3.25 mmol) of 2-(2-amino-5-methylphenyl)-3-methyl-2-cyclopenten-1-one, 0.283 g (3.58 mmol) of pyridine, 0.782 g (3.58 mmol) of 2-mesitylenesulfonyl chloride, and 3 mL of M.C were loaded to a 20 mL vial, and then reacted for 12 hours. The work-up was the same as in Example 7 (1.29 g, 85%).

Workup

  1. customreacted for 12 hours

Sources & evidence

ORD record
ord-804a24e08e7340dc91e86e6c6c13d8a1
Source dataset
uspto-grants-2009_05
Patent number
US07538239B2

Reaction notes

Loading…