Pyridine → 2-(2-(p-Toluenesulfonyl)aminophenyl)-3-methyl-2-cyclopenten-1-one

HRID 495159Notes

Reaction equation

HRID 495159 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9](=[O:14])[CH2:10][CH2:11][C:12]=1[CH3:13].N1C=CC=CC=1.[C:21]1([CH3:31])[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>>[C:21]1([CH3:31])[CH:26]=[CH:25][C:24]([S:27]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[C:8]2[C:9](=[O:14])[CH2:10][CH2:11][C:12]=2[CH3:13])(=[O:29])=[O:28])=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 665938242-(2-Aminophenyl)-3-methylcyclopent-2-en-1-one

Product 1

HCID 665934092-(2-(p-Toluenesulfonyl)aminophenyl)-3-methyl-2-cyclopenten-1-one

Procedure

0.815 g (4.35 mmol) of 2-(2-aminophenyl)-3-methyl-2-cyclopenten-1-one, pyridine 0.413 g (5.22 mmol), 0.829 g (5.22 mmol) of p-toluenesulfonyl chloride, and 4 mL of M.C were loaded to a 20 mL vial, and then reacted for 12 hours. The work-up was the same as in Example 7 (1.330 g, 89%).

Workup

  1. customreacted for 12 hours

Sources & evidence

ORD record
ord-b29e1a67a9804245a63303623f76bfbd
Source dataset
uspto-grants-2009_05
Patent number
US07538239B2

Reaction notes

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