4-Toluenesulfonyl chloride → HCID 66593573, compound

HRID 495161Notes

Reaction equation

HRID 495161 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[C:9]1[C:10](=[O:15])[CH2:11][CH2:12][C:13]=1[CH3:14].[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>N1C=CC=CC=1>[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=2[C:9]2[C:10](=[O:15])[CH2:11][CH2:12][C:13]=2[CH3:14])(=[O:24])=[O:23])=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 66593777HCID 66593777, compound

Product 1

HCID 66593573HCID 66593573, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

0.600 g (2.79 mmol) of 2-(2-amino-5-methylphenyl)-3-methyl-2-cyclopenten-1-one, 0.243 g (3.07 mmol) f pyridine, 0.858 g (3.07 mmol) of p-toluenesulfonyl chloride, and 3 mL of M.C were loaded to a 20 mL vial, and then reacted for 12 hours. The work-up was the same as in Example 7 (0.800 g, 78%).

Workup

  1. customreacted for 12 hours

Sources & evidence

ORD record
ord-c2eb8c6d86484c43bed68c7a275db0a8
Source dataset
uspto-grants-2009_05
Patent number
US07538239B2

Reaction notes

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