反应详情

温度

0 °C

A solution of Meldrum's acid (10 g, 69.4 mmol) in CH2Cl2 (170 mL) was cooled to 0° C. Pyridine (11.2 ml, 138.8 mmol) and propanoyl chloride (10.1 mL, 76.3 mmol) were added via syringe. The resulting solution was stirred at 0° C. for 1 hour, then warmed to room temperature and stirred for 1 hour. The reaction was diluted with CH2Cl2 and washed with aq HCl (15 mL conc HCl in 200 mL water, 1×) and water (1×). The organic solution was dried over Na2SO4 and concentrated to give a dark red solid.

1. temperaturewarmed to room temperature
2. stirringstirred for 1 hour
3. washwashed with aq HCl (15 mL conc HCl in 200 mL water, 1×) and water (1×)
4. dry with materialThe organic solution was dried over Na2SO4
5. concentrationconcentrated
6. customto give a dark red solid