Ammonia → HCID 23147333, compound

Participants

Reaction Steps

In the same manner as in Example 118, 1-[3-(3-ethoxyphenyl)-4,6-bis(methoxycarbonyloxy)-2-(2-methoxyethyl)phenyl]ethanone was obtained from Compound 121 (94 mg, 0.29 mmol) obtained in Example 121, using methyl chlorocarbonate (0.05 mL, 0.65 mmol), triethylamine (0.09 mL, 0.65 mmol) and tetrahydrofuran (3.0 mL); and from the resulting compound, obtained was 2-(3-ethoxyphenyl)-4-ethyl-1,5-bis(methoxycarbonyloxy)-3-(2-methoxyethyl)benzene, using sodium borohydride (30 mg, 0.79 mmol), water (2.0 mL) and tetrahydrofuran (2.0 mL). Then, the resulting compound was treated with methanol solution (5.0 mL) of 7 mmol/L ammonia to obtain Compound 133 (45 mg, 50%).

Provenance & Evidence