反应详情

To 639 mg of 5-[2-carbamoyl-2-(methylthio)ethyl]-2-methoxy-N-(4-trifluoromethylbenzyl)benzamide were added 70 ml of methylene chloride and 368 mg of mCPBA under cooling with ice, and the mixture was stirred for 3 hours. The reaction mixture was washed with saturated aqueous solution of sodium bicarbonate and saturated brine in sequence and dried over anhydrous sodium sulfate. Solvent was distilled off under reduced pressure, and the residue obtained was purified by means of column chromatography (silica gel, methylene chloride:methanol=50:1 to 20:1) to obtain 486 mg of aimed product as colorless crystals.

1. temperatureunder cooling with ice
2. washThe reaction mixture was washed with saturated aqueous solution of sodium bicarbonate and saturated brine in sequence
3. dry with materialdried over anhydrous sodium sulfate
4. distillationSolvent was distilled off under reduced pressure
5. customthe residue obtained
6. customwas purified by means of column chromatography (silica gel, methylene chloride:methanol=50:1 to 20:1)