Sodium Hydroxide → 6-Methoxyquinoline-3-carboxylic acid

Participants

Reaction Steps

To a stirred solution of 6-methoxy-3-ethoxycarbonylquinoline (Step D, 6 g, 0.026 mol) in EtOH (65 mL) was added at RT a 2N aqueous solution of NaOH (26 mL, 0.052 mol). The reaction mixture was stirred at RT overnight. After concentration under vacuum, the mixture was acidified with 1N HCl and the resulting solid was filtered off, washed with water and dried over P2O5 to give 6-methoxy-3-carboxyquinoline.

Provenance & Evidence