Sodium Hydroxide → 6-Methoxyquinoline-3-carboxylic acid

HRID 495469ノート

反応式

HRID 495469 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([O:15]CC)=[O:14])=[CH:6]2.[OH-].[Na+]>CCO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([OH:15])=[O:14])=[CH:6]2

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 304668Ethyl 6-methoxyquinoline-3-carboxylate

生成物 1

HCID 142415026-Methoxyquinoline-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 6-methoxy-3-ethoxycarbonylquinoline (Step D, 6 g, 0.026 mol) in EtOH (65 mL) was added at RT a 2N aqueous solution of NaOH (26 mL, 0.052 mol). The reaction mixture was stirred at RT overnight. After concentration under vacuum, the mixture was acidified with 1N HCl and the resulting solid was filtered off, washed with water and dried over P2O5 to give 6-methoxy-3-carboxyquinoline.

後処理

  1. concentrationAfter concentration under vacuum
  2. filtrationthe resulting solid was filtered off
  3. washwashed with water
  4. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-38efa593a139420c9de76b8bcc246134
出典データセット
uspto-grants-2005_09
特許番号
US06939874B2

反応ノート

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