Methyl 2-(1-methylpiperidin-4-ylidene)acetate → Methyl 2-(1-methylpiperidin-4-yl)acetate

HRID 495482Notes

Reaction equation

HRID 495482 reaction equation
[CH3:1][O:2][C:3](=[O:12])[CH:4]=[C:5]1[CH2:10][CH2:9][N:8]([CH3:11])[CH2:7][CH2:6]1>[Pd].CCO>[CH3:1][O:2][C:3](=[O:12])[CH2:4][CH:5]1[CH2:6][CH2:7][N:8]([CH3:11])[CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 20672702Methyl 2-(1-methylpiperidin-4-ylidene)acetate

Product 1

HCID 19425952Methyl 2-(1-methylpiperidin-4-yl)acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

(1-Methyl-piperidin-4-ylidene)-acetic acid methyl ester (Step A) was stirred under H2 overnight (1.1 g of 10% Pd/C and 200 mL EtOH), filtered and evaporated to give (1-methyl-piperidin-4-yl)-acetic acid methyl ester as a yellow oil/white solid.

Workup

  1. filtrationfiltered
  2. customevaporated

Sources & evidence

ORD record
ord-dacca3ed436b4d0f94be5b29df70d83f
Source dataset
uspto-grants-2005_09
Patent number
US06939874B2

Reaction notes

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