6-(N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane → 6-[4(4-(5-Ethoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

HRID 4955Notes

Reaction equation

HRID 4955 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][C:13]([C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:14][C:9]=2[N:8]=[CH:7]1.Cl[CH2:21][CH2:22][N:23]([C:27]1[CH:36]=[CH:35][C:30]2[O:31][CH2:32][CH2:33][O:34][C:29]=2[CH:28]=1)[CH2:24][CH2:25]Cl>>[CH2:18]([O:17][C:15]([C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:1]3[CH2:25][CH2:24][N:23]([C:27]4[CH:36]=[CH:35][C:30]5[O:31][CH2:32][CH2:33][O:34][C:29]=5[CH:28]=4)[CH2:22][CH2:21]3)[CH:7]=[N:8][C:9]=2[CH:14]=1)=[O:16])[CH3:19]

Participants

3

Reactant 2

HCID 197973136-(N,N-bis(2-chloroethyl)amino)-1,4-benzodioxaneHCID 197973351-(4-Aminobutyl)-5-ethoxycarbonylbenzimidazole

Product 1

HCID 197973226-[4(4-(5-Ethoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane

Procedure

Analogously to Example 3, reaction of 1-(4-aminobutyl)-5-ethoxycarbonylbenzimidazole with 6-(N,N-bis(2-chloroethyl)amino)-1,4-benzodioxane ("B") gives 6-[4(4-(5-ethoxycarbonylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.

Sources & evidence

ORD record
ord-776d210858d547fca9d654d698089e84
Source dataset
uspto-grants-1993_09
Patent number
US05242925

Reaction notes

Loading…