反应详情

4-Chlorobenzylamine (1.0556 g) was dissolved in pyridine (5 ml), and to the solution was added dropwise ethyl chloroformate.(0.855 ml) during 5 minutes under ice-cooling. After the mixture was stirred for 3 hours, 1N hydrochloric acid was added and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, saturated aqueous sodium bicarbonate solution, and then saturated brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (1.562 g, 98%).

1. temperature(0.855 ml) during 5 minutes under ice-cooling
2. extractionthe mixture was extracted with ethyl acetate
3. washThe organic layer was washed with 1N hydrochloric acid, saturated aqueous sodium bicarbonate solution
4. dry with materialsaturated brine, dried over anhydrous magnesium sulfate
5. concentrationconcentrated in vacuo