Sodium hydride → 5-amino-1-(4-chlorobenzyl)-7-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one

HRID 495628ノート

反応式

HRID 495628 の反応式
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][C:16]([NH2:23])=[CH:15][C:14]=2[NH2:24])[C:8](=O)[O:9]CC)=[CH:4][CH:3]=1.[H-].[Na+].C(=O)(O)[O-].[Na+]>C(O)C>[NH2:23][C:16]1[CH:17]=[C:18]([C:19]([F:22])([F:20])[F:21])[C:13]2[N:7]([CH2:6][C:5]3[CH:25]=[CH:26][C:2]([Cl:1])=[CH:3][CH:4]=3)[C:8](=[O:9])[NH:24][C:14]=2[CH:15]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 516892Sodium BicarbonateHCID 20827745Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

生成物 1

HCID 223273785-amino-1-(4-chlorobenzyl)-7-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one収率 35.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate (248.7 mg) was dissolved in ethanol (15 ml), and to the solution was added sodium hydride (51.3 mg). The reaction mixture was heated at reflux for 15 hours. After allowing to cool, to the reaction mixture was added saturated aqueous sodium bicarbonate solution, and the mixture was extracted 3 times with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The resultant residue was purified by preparative TLC (2 mm, 20×20 cm, CHCl3-methanol=10:1) to give the title compound (78.4 mg).

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 15 hours
  3. temperatureto cool, to the reaction mixture
  4. extractionthe mixture was extracted 3 times with chloroform
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. concentrationconcentrated in vacuo
  8. customThe resultant residue was purified by preparative TLC (2 mm, 20×20 cm, CHCl3-methanol=10:1)

出典と根拠

ORDレコード
ord-414e5dda2274483581a15b9f8bb8a43a
出典データセット
uspto-grants-2005_09
特許番号
US06939887B2

反応ノート

読み込み中…