Hydrochloric Acid → HCID 10168581, compound

Participants

Reaction Steps

0.5 ml (2 mmol) of a 4-molar solution of HCl in dioxane is added to a solution of 220 mg of 4-{[(4-carboxybutyl)(2-{2-[(3-fluoro-4′-trifluoromethyl-1,1′-biphenyl4-yl)methoxy]phenyl}ethyl)amino]methyl}benzoic acid from Ex. 3 in 0.2 ml of dioxane, and the mixture is stirred at 60° C. for 1 h. The mixture is then concentrated by evaporation and the resulting colorless oil is triturated repeatedly with diethyl ether. The resulting crystals are filtered and dried.

Provenance & Evidence