Hydrochloric Acid → HCID 10168581, compound

HRID 495695Notes

Reaction equation

HRID 495695 reaction equation
[ClH:1].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:37][C:38]1[CH:46]=[CH:45][C:41]([C:42]([OH:44])=[O:43])=[CH:40][CH:39]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=2)=[CH:22][C:21]=1[F:36])([OH:4])=[O:3]>O1CCOCC1>[ClH:1].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][N:9]([CH2:37][C:38]1[CH:46]=[CH:45][C:41]([C:42]([OH:44])=[O:43])=[CH:40][CH:39]=1)[CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:34])([F:35])[F:33])=[CH:28][CH:27]=2)=[CH:22][C:21]=1[F:36])([OH:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10121897HCID 10121897, compound

Product 1

HCID 10168581HCID 10168581, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

0.5 ml (2 mmol) of a 4-molar solution of HCl in dioxane is added to a solution of 220 mg of 4-{[(4-carboxybutyl)(2-{2-[(3-fluoro-4′-trifluoromethyl-1,1′-biphenyl4-yl)methoxy]phenyl}ethyl)amino]methyl}benzoic acid from Ex. 3 in 0.2 ml of dioxane, and the mixture is stirred at 60° C. for 1 h. The mixture is then concentrated by evaporation and the resulting colorless oil is triturated repeatedly with diethyl ether. The resulting crystals are filtered and dried.

Workup

  1. concentrationThe mixture is then concentrated by evaporation
  2. customthe resulting colorless oil is triturated repeatedly with diethyl ether
  3. filtrationThe resulting crystals are filtered
  4. customdried

Sources & evidence

ORD record
ord-19feb318d36a4bbe85261f291c7fd951
Source dataset
uspto-grants-2005_09
Patent number
US06939989B2

Reaction notes

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