反应详情

温度

70 °C

A mixture of 2,5-dibromopyridine (100 g), N-formylpropargylamine (87.7 g), PdCl2(PPh3)2 (2.96 g), and CuI (0.2 g) in diisopropylamine (3 L) was heated at 70° C. for 6 h under a nitrogen atmosphere. The mixture was cooled to 20-22° C. and filtered. The cake was dried and then slurried in water (3 L) at 0-5° C. for 3 h. The slurry was filtered, and the cake was dried to afford 95.4 g of the title compound 9-1.

1. temperatureThe mixture was cooled to 20-22° C.
2. filtrationfiltered
3. customThe cake was dried
4. filtrationThe slurry was filtered
5. customthe cake was dried