HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylene Glycol Monoethyl Ether → 6-[4-(4-(5-Carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylene Glycol Monoethyl Ether | HCID 8146 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-[4-(4-(5-Cyanobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797317 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-[4-(4-(5-Carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane | HCID 19797326 | — |
Reaction Steps
A mixture of 4.16 g of 6-[4-(4-(5-cyanobenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane, 2.4 g of NaOH, 50 ml of H2O and 40 ml of diethylene glycol monoethyl ether is stirred at a bath temperature of 140° for 3 hours. The mixture is then cooled to room temperature, worked up in the conventional manner and gives 6-[4-(4-(5-carbamoylbenzimidazol-1-yl)butyl)piperazino]-1,4-benzodioxane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242925 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-a782508ad5da4e58a935bed7bb6cedd1 |
| Source note | uspto-grants-1993_09 |