HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Monomethyl cyclopropane-1,1-dicarboxylate | HCID 22325078 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid | HCID 13861823 | — |
Reaction Steps
1.45 liters of 1N sodium hydroxide solution are added to a solution, cooled to 5° C., of 1.45 ml of methyl 1,1-cyclopropanedicarboxylate in 2.5 liters of methanol. After stirring for 4 days at ambient temperature, the mixture is three-quarters concentrated, extracted with ether and then treated in customary manner, allowing the expected product to be isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06943184B2 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-4a70eccecef643dd8b83003fe0b11ca1 |
| Source note | uspto-grants-2005_09 |