HCID 69733885, compound → HCID 22325162, compound

HRID 496063Notes

Reaction equation

HRID 496063 reaction equation
[C:1]([O:5][C:6]([N:8]([CH3:19])[C:9]1([CH:12]=[CH:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]([CH3:19])[C:9]1([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 69733885HCID 69733885, compound

Product 1

HCID 22325162HCID 22325162, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

8.0 g of the product obtained in Step 2 dissolved in 200 ml of ethanol are hydrogenated for 4 hours at 20° C. and 5 bar in the presence of 1.0 g of 10% palladium-on-carbon. After filtering and concentrating to dryness, chromatography over silica gel (dichloromethane/tetrahydrofuran: 97/3) allows the expected product to be isolated (liquid).

Workup

  1. filtrationAfter filtering
  2. concentrationconcentrating to dryness, chromatography over silica gel (dichloromethane/tetrahydrofuran: 97/3)
  3. customto be isolated (liquid)

Sources & evidence

ORD record
ord-89c979722a4143e083796a5eafef7136
Source dataset
uspto-grants-2005_09
Patent number
US06943184B2

Reaction notes

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