Hydrochloric Acid → HCID 22325164, compound

HRID 496073Notes

Reaction equation

HRID 496073 reaction equation
[CH3:1][N:2]([C:10]1([CH2:13][O:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:12][CH2:11]1)C(=O)OC(C)(C)C.[ClH:21]>O1CCOCC1.CCOCC>[ClH:21].[CH3:1][NH:2][C:10]1([CH2:13][O:14][C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:12][CH2:11]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22325115HCID 22325115, compound

Product 1

HCID 22325164HCID 22325164, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent2×

Procedure

A solution containing 0.32 g of the compound obtained in Step 1 in 3 ml of dioxane and 3 ml of 4N hydrochloric acid in dioxane is stirred at ambient temperature and under an inert atmosphere, and is then diluted with ether. The liquid phase is then separated off and the residue is taken up in 25 ml of ethanol. The solution is concentrated to 2 ml and is then diluted with 20 ml of ether and stirred; the precipitate formed is filtered off, rinsed and dried, allowing the expected product to be isolated.

Workup

  1. customThe liquid phase is then separated off
  2. concentrationThe solution is concentrated to 2 ml
  3. additionis then diluted with 20 ml of ether
  4. stirringstirred
  5. customthe precipitate formed
  6. filtrationis filtered off
  7. washrinsed
  8. customdried
  9. customto be isolated

Sources & evidence

ORD record
ord-f2f26c38417f41a5bb7af2d22e383d12
Source dataset
uspto-grants-2005_09
Patent number
US06943184B2

Reaction notes

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