Trifluoroacetic acid → HCID 13606208, compound

HRID 496219Notes

Reaction equation

HRID 496219 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([NH:13][C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:20][C:17]1[CH:16]=[CH:15][C:14]([NH:13][CH:10]2[CH2:11][CH2:12][NH:8][CH2:9]2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22313565HCID 22313565, compound

Product 1

HCID 13606208HCID 13606208, compoundYield 215.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert.butyl-3-(4-chloroanilino)-1-pyrrolidinecarboxylate (130 mg, 0.438 mmol) in CH2Cl2 (5 mL) was added CF3COOH (1 mL). After 30 min tie volatiles were removed in vacuo to give the subtitled product (186 mg) and was used directly in the next step.

Workup

  1. customAfter 30 min tie volatiles were removed in vacuo

Sources & evidence

ORD record
ord-a6319b26f4634bbebaeabe15b897c3b2
Source dataset
uspto-grants-2005_09
Patent number
US06943188B2

Reaction notes

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