反应详情

To a solution of N-BOC-2-methyl-4-(S)-phenyl-(L)-proline, methyl ester from Step B (1.85 g, 5.8 mmol) in MeOH was bubbled HCl (g) over a 10 min period. The HCl saturated solution was allowed to stir at rt for 5 h, concentrated in vacuo and azeotroped with toluene. The crude product was used in the subsequent step.

1. concentrationconcentrated in vacuo
2. customazeotroped with toluene