Trifluoroacetic acid → HCID 69352425, compound

HRID 496236Notes

Reaction equation

HRID 496236 reaction equation
C([N:8]1[CH2:15][CH2:14][C@H:13]([CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C@H:9]1[C:10]([OH:12])=[O:11])(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:16]1([C@H:13]2[CH2:14][CH2:15][NH:8][C@@H:9]2[C:10]([OH:12])=[O:11])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69352438HCID 69352438, compound

Product 1

HCID 69352425HCID 69352425, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of N-BOC-3(R)-cyclohexyl-(L)-proline from step A (1.0 g, 0.28 mmol) in CH2Cl2 (3 mL) at 0° C. was added TFA (6 mL). The reaction was allowed to warm to rt for 4 h. The reaction was then concentrated in vacuo and azeotroped with toluene. The crude product was used in the subsequent reaction.

Workup

  1. concentrationThe reaction was then concentrated in vacuo
  2. customazeotroped with toluene
  3. customThe crude product was used in the subsequent reaction

Sources & evidence

ORD record
ord-11996c94b007499f8d6549403dae714e
Source dataset
uspto-grants-2005_09
Patent number
US06943180B2

Reaction notes

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