N-(2-nitro-4-trifluoromethylsulfonyl-phenyl)-acetamide → 2-Nitro-4-(trifluoromethanesulfonyl)aniline

HRID 496258Notes

Reaction equation

HRID 496258 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([C:13]([F:16])([F:15])[F:14])(=[O:12])=[O:11])[CH:7]=[CH:6][C:5]=1[NH:17]C(=O)C)([O-:3])=[O:2]>Cl.O>[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([C:13]([F:16])([F:14])[F:15])(=[O:11])=[O:12])[CH:7]=[CH:6][C:5]=1[NH2:17])([O-:3])=[O:2]

Participants

4

Reactant 1

HCID 22325341N-(2-nitro-4-trifluoromethylsulfonyl-phenyl)-acetamide

Product 1

HCID 45294692-Nitro-4-(trifluoromethanesulfonyl)aniline

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

Reflux N-(2-nitro-4-trifluoromethylsulfonyl-phenyl)-acetamide (600 mg) for 40 minutes in concentrated HCl (15 mL) and water (5 mL). Cool the mixture to room temperature and collect the precipitate obtain 2-nitro-4-trifluoromethylsulfonyl-phenylamine. D. 4-Trifluoromethylsulfonyl-benzene-1,2-diamine

Workup

  1. customcollect the precipitate

Sources & evidence

ORD record
ord-b3f5690884f442e4970001d0a724d8cb
Source dataset
uspto-grants-2005_09
Patent number
US06943199B2

Reaction notes

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