HRID496260

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

HCID2063462

4-(Trifluoromethanesulfonyl)benzene-1,2-diamine

C7H7F3N2O2S

PRODUCTS

生成物

结构：O=c1[nH]c2ccc(S(=O)(=O)C(F)(F)F)cc2[nH]1

HCID15484057

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Reflux 4-trifluoromethylsulfonyl-benzene-1,2-diamine (420 mg) and CDI (284 mg) for 16 hours in CH3CN (30 mL). Evaporate the solvent in vacuo. Purify by flash chromatography (1:1 hexanes/EtOAc) to obtain 5-trifluoromethylsulfonyl-1,3-dihydro-benzimidazol-2-one. F. 2-Chloro-5-trifluoromethylsulfonyl-1H-benzimidazole

WORKUP

后处理

customEvaporate the solvent in vacuo
customPurify by flash chromatography (1:1 hexanes/EtOAc)