反应详情

Add 1,1′-carbonyldiimidazole (1.0 g, 6.17 mmol) to a solution of 5-trifluoromethyl-pyridine-2,3 diamine (0.90 g, 5.08 mmol) in CH2Cl2 (10 mL) and stir at room temperature for 18 hours. Heat the solution to reflux for 2 hours and filter the precipitate to obtain 6-trifluoromethyl-1,3-dihydro-imidazo[4,5-b]pyridin-2-one. C. 2-Chloro-6-trifluoromethyl-3-H-imidazo[4,5-b]pyridine

1. temperatureHeat the solution
2. temperatureto reflux for 2 hours
3. filtrationfilter the precipitate