Hydrochloric Acid → 5-aminomethyl-6-((S)-2-imidazol-1-yl-1-phenyl-ethoxy)-3,4-dihydro-2H-naphthalen-1-one bis-hydrochloride

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Reaction Steps

[2-((S)-2-Imidazol-1-yl-1-phenyl-ethoxy)-5-oxo-5,6,7,8-tetrahydro-naphthalen-1-ylmethyl]-carbamic acid tert-butyl ester (0.830 g, 1.80 mmol) was dissolved in dioxane (10 mL) and 4M HCl in dioxane (4 mL) was added. After 15 minutes, a white precipitate formed. The precipitate was collected by filtration, washed with Et2O and dried in a vacuum oven to give the title compound as a white fluffy solid (0.761 g, 1.75 mmol, 97%). The structure was confirmed by NMR, mass spectrometry and elemental analysis. MS m/z 362 (M++H).

Provenance & Evidence