反应详情

[2-((S)-2-Imidazol-1-yl-1-phenyl-ethoxy)-5-oxo-5,6,7,8-tetrahydro-naphthalen-1-ylmethyl]-carbamic acid tert-butyl ester (0.830 g, 1.80 mmol) was dissolved in dioxane (10 mL) and 4M HCl in dioxane (4 mL) was added. After 15 minutes, a white precipitate formed. The precipitate was collected by filtration, washed with Et2O and dried in a vacuum oven to give the title compound as a white fluffy solid (0.761 g, 1.75 mmol, 97%). The structure was confirmed by NMR, mass spectrometry and elemental analysis. MS m/z 362 (M++H).

1. customa white precipitate formed
2. filtrationThe precipitate was collected by filtration
3. washwashed with Et2O
4. customdried in a vacuum oven