HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 49648Generated: October 29, 2026
Trimethyl orthoacetate → Methyl 4,5-bismethanesulfonyl-2-methylbenzoate
https://huagongshe.com/reaction/49648
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | 4-chloro-2-methyl-5-(methylsulfonyl)Benzoic acid | HCID 10824478 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Methyl 4,5-bismethanesulfonyl-2-methylbenzoate | HCID 11738318 | — |
Reaction Steps
A solution of 100.0 g of 4-chloro-5-methanesulfonyl-2-methylbenzoic acid and 68.1 g of trimethyl orthoacetate in 322 ml of NMP was refluxed until the acid had reacted completely. After the excess orthoester had been distilled off, 96.5 g of sodium methanesulfinate were added, and the mixture was stirred at 90° C. for 18 h. Conventional work-up gave methyl 4,5-bis-methanesulfonyl-2-methylbenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06706921B2 |
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| Source dataset | uspto-grants-2004_03 |
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| ORD ID | ord-7728b859049a420483ed9f879c6ba36d |
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| Source note | uspto-grants-2004_03 |
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