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HRID49648

反应详情

EQUATION

反应方程式

HRID 49648 的结构方程式

REACTANTS

反应物

2
结构：COC(C)(OC)OC
HCID15050

1,1,1-Trimethoxyethane

C5H12O3

结构：Cc1cc(Cl)c(S(C)(=O)=O)cc1C(=O)O
HCID10824478

4-Chloro-2-methyl-5-(methylsulfonyl)benzoic acid

C9H9ClO4S

PRODUCTS

生成物

1
结构：COC(=O)c1cc(S(C)(=O)=O)c(S(C)(=O)=O)cc1C
HCID11738318

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

CONDITIONS

反应条件

温度
90 °C

PROCEDURE

实验过程

A solution of 100.0 g of 4-chloro-5-methanesulfonyl-2-methylbenzoic acid and 68.1 g of trimethyl orthoacetate in 322 ml of NMP was refluxed until the acid had reacted completely. After the excess orthoester had been distilled off, 96.5 g of sodium methanesulfinate were added, and the mixture was stirred at 90° C. for 18 h. Conventional work-up gave methyl 4,5-bis-methanesulfonyl-2-methylbenzoate.

WORKUP

后处理

  1. customhad reacted completely
  2. distillationAfter the excess orthoester had been distilled off
  3. addition96.5 g of sodium methanesulfinate were added