HCID 11278269, compound → HCID 69742386, compound

HRID 496523Notes

Reaction equation

HRID 496523 reaction equation
[Cl-:1].[CH3:2][N+:3]1[CH:7]=[CH:6][N:5]([CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([N+:19]([O-])=O)=[CH:15][CH:14]=3)[CH2:9]2)[CH:4]=1>C(O)C.[Pd]>[ClH:1].[Cl-:1].[CH3:2][NH+:3]1[CH:7]=[CH:6][N:5]([CH:8]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][C:16]([NH2:19])=[CH:15][CH:14]=3)[CH2:9]2)[CH2:4]1

Participants

4

Reactant 1

HCID 11278269HCID 11278269, compound

Product 1

HCID 69742386HCID 69742386, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

16 g (0.0518 mol) of the preceding derivative (4) dissolved in 600 ml of ethanol was hydrogenated in the presence of palladium-on-charcoal under a hydrogen pressure of 8 bar. After filtering off the catalyst, the expected derivative (5) was isolated in the form of the hydrochloride.

Workup

  1. filtrationAfter filtering off the catalyst

Sources & evidence

ORD record
ord-fe33e128ca304317b042b5e670a9cbdf
Source dataset
uspto-grants-2005_09
Patent number
US06946005B2

Reaction notes

Loading…