反应详情

2.07 g (0.01 mol) of [1-(4-nitrophenyl)pyrrolidin-3-yl]amine (2) was heated to 90° C. in 10 ml of DMF. 1.32 g (0.0009 mol) of 1-amidinopyrazole monohydrochloride was added slowly to the reaction medium. The mixture was heated for 8 hours. A yellow solid was thus precipitated. The solid thus obtained was filtered off, washed with ethanol and dried under vacuum to give 2 g of a yellow powder (3) (70%).

1. temperatureThe mixture was heated for 8 hours
2. customA yellow solid was thus precipitated
3. customThe solid thus obtained
4. filtrationwas filtered off
5. washwashed with ethanol
6. customdried under vacuum