反应详情

Compound 26 in methanol was treated with SO2Cl2 and the resulting solution heated at reflux for18 h. The reaction mixture was then evaporated, pre-absorbed on silica (Merck, 9385) and purified by chromatography, eluting with 10% ethyl acetate/i-hexane. Appropriate fractions were combined and evaporated to give methyl 2-bromo-4-nitro-benzoate (compound 27).

1. temperaturethe resulting solution heated
2. temperatureat reflux for18 h
3. customThe reaction mixture was then evaporated
4. custompre-absorbed on silica (Merck, 9385)
5. custompurified by chromatography
6. washeluting with 10% ethyl acetate/i-hexane
7. customevaporated