HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2-Bromo-4-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 2-Bromo-4-nitrobenzoic acid | HCID 313534 | — |
| Product | Methyl 2-Bromo-4-nitrobenzoate | HCID 15833211 | — |
Reaction Steps
Compound 26 in methanol was treated with SO2Cl2 and the resulting solution heated at reflux for18 h. The reaction mixture was then evaporated, pre-absorbed on silica (Merck, 9385) and purified by chromatography, eluting with 10% ethyl acetate/i-hexane. Appropriate fractions were combined and evaporated to give methyl 2-bromo-4-nitro-benzoate (compound 27).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06946468B1 |
| Source dataset | uspto-grants-2005_09 |
| ORD ID | ord-dff9c183e7ac4755bae7a188497d9847 |
| Source note | uspto-grants-2005_09 |