m-Chloroperbenzoic acid → HCID 69781579, compound

HRID 496658Notes

Reaction equation

HRID 496658 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[C:9]1[N:10]([OH:30])[C:11]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([S:28][CH3:29])[N:23]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20][CH3:21])[CH:15]=2)[N:13]=1.ClC1C=CC=C(C(OO)=[O:39])C=1>ClCCl>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[C:9]1[N:10]([OH:30])[C:11]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([S:28]([CH3:29])=[O:39])[N:23]=2)=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([S:20][CH3:21])[CH:15]=2)[N:13]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 69503100HCID 69503100, compound

Product 1

HCID 69781579HCID 69781579, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 480 mg (1 mmol) E16.1 in 3 ml dichloromethane a solution of 246 mg (1 mmol) 3-chloroperbenzoic acid in 7 ml dichloromethane was added at 0° C. and stirred at this temperature for 6 hours. After washing with 5% aqueous sodium hydrogencarbonate and water (each 0° C.) the organic layer was dried over sodium sulfate and evaporated to dryness to yield 470 mg G16.1.1 (96%).

Workup

  1. washAfter washing with 5% aqueous sodium hydrogencarbonate and water (each 0° C.) the organic layer
  2. dry with materialwas dried over sodium sulfate
  3. customevaporated to dryness
  4. customto yield 470 mg G16.1.1 (96%)

Sources & evidence

ORD record
ord-fe953ba803d845e5a5c20b214ec43188
Source dataset
uspto-grants-2005_09
Patent number
US06946471B2

Reaction notes

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